PK/PD Simulation
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PK model
1-compartment model
2-compartment model
3-compartment model
MM Clearance
no
yes
PD model
PD model
Indirect(Kin-Inhibition)
Indirect(Kin-Stimulation)
Indirect(Kout-Inhibition)
Indirect(Kout-Stimulation)
Direct model
Tumorgrowth(exp-kin)
Tumorgrowth(exp-kout)
Tumorgrowth(logi-kin)
Tumorgrowth(logi-kout)
input type
PO
IV
Additional PO option
First-order
Zero-order
Weibull
First-zero
Zero-First
Transit
pop simulation
Dose (mg)
Time after loading(hr)
Bolus vs Infusion
Bolus
Infusion
Infusion time(hr)
Loading dose
Dose(mg)
Dosing interval (hr)
No.of Dosing
Multiple dose
No.of Dosing
Dosing interval (hr)
Different dose
Start dose(mg)
End dose(mg)
Step(mg)
RUN
.csv Download
nca Download
PK
PD
BSV
Clearance (CL, L/h)
Volume of distribution(Vd, L)
Clearance (CL, L/h)
Central volume(Vc, L)
Peripheral volume(Vp, L)
Intercompartmental clearance (Q, L/h)
Peripheral volume2(Vp2, L)
Intercompartmental clearance2 (Q2, L/h)
Absorption rate constant (ka, 1/h)
Duration (D, h)
Weibull-Alpha
Weibull-beta
MTT
N
F1
ALAG1
ALAG2
ALAG
Bioavailability(F)
MM_VMAX (ug/h)
MM_KM (ng/mL)
Kin
Base
EC50 (ng/mL)
EMAX
IC50 (ng/mL)
IMAX
Kout
TVss(m3)
EC50 (ng/mL)
EMAX
hill coefficient
Clearance (CL)
Volume of distribution(Vd)
Clearance (CL, L/h)
Central volume(Vc, L)
Peripheral volume(Vp, L)
Intercompartmental clearance (Q, L/h)
Peripheral volume2(Vp2, L)
Intercompartmental clearance2 (Q2, L/h)
Absorption rate constant (ka, 1/h)
Weibull-Alpha
Weibull-beta
Bioavailability(F)
MM_VMAX (ug/h)
MM_KM (ng/mL)
Kin
Base
EC50
EMAX
IC50
IMAX
Kout
TVss
EC50
EMAX
hill coefficient
Simulation option
Delta (h)
Population No.
Add error
prop error
NCA option
AUC_Start
AUC_End
Image size contol
Image size (height x width)
dpi
PK
PD
PK/PD
Plotly
Abline
name
ng/mL
Abline
name
ng/mL
Add
plot
Dose unit
x_axis
y_axis
Abline
name
Abline
name
Add
plot
plot
Reference plot
save
Reference plot
save